The human immunodeficiency virus type 1 (HIV-1) Vif protein plays a critical role in virus
replication and infectivity. Here we show that Vif is phosphorylated and regulated by p44/42 …

Nef is a lentiviral protein involved in pathogenesis of AIDS, but its molecular mechanisms of
action remain incompletely understood. Here we report a novel effect of Nef on lymphocyte …

Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …

Acute HIV infection is often accompanied by a flu-like illness and is associated with a high-
titer viremia. This viremia is quickly controlled by the immune response, mediated …

Background The primate lentiviruses, human immunodeficiency virus types 1 and 2 (HIV-1
and HIV-2) and simian immunodeficiency virus (SIV), encode a conserved accessory gene …

HIV-1 Nef has previously been shown to bind to Src homology-3 (SH3) domains of a subset
of Src family tyrosine kinases. In addition, Nef has been reported to coprecipitate with a …

The sequence of events leading to clathrin-coated pit (CCP) nucleation on the cell surface
and to the incorporation of receptors into these endocytic structures is still imperfectly …

Although initially recognised as essential for the entry of certain viruses, endocytosis is now
known to also play important roles in the replication of, and adaptation to, the host cell of a …

HIV-1 pathogenicity factor Nef has been shown to modulate calcium signaling in host cells,
but the underlying molecular mechanisms have remained unclear. Here we show that …

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in
monkeys and in humans. Among a human cohort of long‐term non‐progressors, several Nef …