Gout, the most prevalent inflammatory arthritis worldwide, is associated with cardiovascular
and renal diseases, and is an independent predictor of premature death. The frequencies of …

Macrovascular complications of diabetes, including diabetic cardiovascular disease (CVD),
occur through a number of hyperglycaemia-induced mechanisms that include generation of …

Hyperuricemia has long been established as the major etiologic factor in gout. Alongside
with an inflammatory state triggered by urate crystal deposition in the joints, hyperuricemia …

Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly
considered a true risk factor. Recent studies suggest that uric acid is biologically active and …

Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome
through the oxidative stress and the inflammatory response induced by XOR-derived …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Epidemiological and experimental studies have shown that hyperuricaemia and gout are
intricately linked with hypertension, metabolic syndrome, chronic kidney disease and …

Uric acid is the end product of purine metabolism in humans. High levels are causative in
gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of …

Oxidative stress plays a dual role in infections. Free radicals protect against invading
microorganisms, and they can also cause tissue damage during the resulting inflammation …

This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …