Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

J Li, S Zheng, Y Fan, K Tan - Cell Death & Disease, 2023 - nature.com
Kidney diseases remain one of the leading causes of human death and have placed a
heavy burden on the medical system. Regulated cell death contributes to the pathology of a …

Novel insight into ferroptosis in kidney diseases

L Yang, Y Liu, S Zhou, Q Feng, Y Lu, D Liu… - American Journal of …, 2023 - karger.com
Background: Various kidney diseases such as acute kidney injury, chronic kidney disease,
polycystic kidney disease, renal cancer, and kidney stones, are an important part of the …

Vitexin attenuates chronic kidney disease by inhibiting renal tubular epithelial cell ferroptosis via NRF2 activation

J Song, H Wang, J Sheng, W Zhang, J Lei, W Gan… - Molecular …, 2023 - Springer
Background Chronic kidney disease (CKD) involves a variety of pathological processes, and
ferroptosis plays a vital role in CKD progression. Targeting ferroptosis is a promising …

Bibliometric analysis of ferroptosis in acute kidney injury from 2014 to 2022

C Liu, W Zhou, Z Mao, X Li, Q Meng, R Fan… - … Urology and Nephrology, 2023 - Springer
Introduction Acute kidney injury (AKI) is a global disease with high morbidity and mortality. At
present, the treatment of AKI still lacks targeted measures. Ferroptosis, a form of regulated …

The effect of Ferroptosis-related Mitochondrial Dysfunction in the Development of Temporal Lobe Epilepsy

Y Su, N Cao, D Zhang, M Wang - Ageing Research Reviews, 2024 - Elsevier
Temporal lobe epilepsy (TLE) is the most common form of epileptic syndrome. It has been
established that due to its complex pathogenesis, a considerable proportion of TLE patients …

Identification and validation of an immunotherapeutic signature for colon cancer based on the regulatory patterns of ferroptosis and their association with the tumor …

Y Liu, J Zhao, B Huang, Y Liang, G Jiang… - … et Biophysica Acta (BBA …, 2024 - Elsevier
The integrated landscape of ferroptosis regulatory patterns and their association with colon
microenvironment have been demonstrated in recent studies. However, the ferroptosis …

Mitochondrial quality control in acute kidney disease

J Sheng, X Li, J Lei, WH Gan, J Song - Journal of nephrology, 2023 - Springer
Acute kidney disease (AKD) involves multiple pathogenic mechanisms, including
maladaptive repair of renal cells that are rich in mitochondria. Maintenance of mitochondrial …

Functional consequence of Iron dyshomeostasis and ferroptosis in systemic lupus erythematosus and lupus nephritis

L Morel, Y Scindia - Clinical Immunology, 2024 - Elsevier
Systemic lupus erythematosus (SLE) and its renal manifestation Lupus nephritis (LN) are
characterized by a dysregulated immune system, autoantibodies, and injury to the renal …

Mitochondrial iron regulation as an emerging target in ischemia/reperfusion injury during kidney transplantation

Y Qi, M Hu, Z Wang, W Shang - Biochemical Pharmacology, 2023 - Elsevier
The injury caused by ischemia and subsequent reperfusion (I/R) is inevitable during kidney
transplantation and its current management remains unsatisfactory. Iron is considered to …

Rosmarinic acid plus deferasirox inhibits ferroptosis to alleviate crush syndrome-related AKI via Nrf2/Keap1 pathway

O Qiao, L Zhang, L Han, X Wang, Z Li, F Bao, H Hao… - Phytomedicine, 2024 - Elsevier
Abstract Background Myoglobin (Mb) induced death of renal tubular epithelial cells (RTECs)
is a major pathological factor in crush syndrome-related acute kidney injury (CS-AKI). It is …