Airway smooth muscle regulated by oxidative stress in COPD

H Kume, R Yamada, Y Sato, R Togawa - Antioxidants, 2023 - mdpi.com
Since COPD is a heterogeneous disease, a specific anti-inflammatory therapy for this
disease has not been established yet. Oxidative stress is recognized as a major …

Antioxidant intake and biomarkers of asthma in relation to smoking status—a review

NA Alsharairi - Current Issues in Molecular Biology, 2023 - mdpi.com
Asthma is considered a chronic inflammatory disorder associated with airway
hyperresponsiveness (AHR). Increased oxidative stress (OS) is a clinical feature of asthma …

Research on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease

T Wang, P Fu, F Long, S Liu, S Hu, Q Wang… - European Journal of …, 2023 - Springer
Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in
treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data …

Involvement of Lysophospholipids in Pulmonary Vascular Functions and Diseases

H Kume, R Harigane, M Rikimaru - Biomedicines, 2024 - mdpi.com
Extracellular lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine,
sphingosine 1-phosphate, etc.), which are synthesized from phospholipids in the cell …

Human beta defensin 3 knockdown inhibits the proliferation and migration of airway smooth muscle cells through regulating the PI3K/AKT signaling pathway

G Chen, Y Zheng, N Wu, X Yang, S Qu - Molecular Immunology, 2024 - Elsevier
Asthma, a common pediatric pulmonary disease, significantly affects children's healthy
development. This study aimed to investigate the functions of human β defensin-3 (HBD-3) …

M2 muscarinic receptor-dependent contractions of airway smooth muscle are inhibited by activation of β-adrenoceptors

T Alkawadri, PY Wong, Z Fong, FT Lundy… - Function, 2022 - academic.oup.com
Abstract Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth
muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 …

LY333531 attenuates contraction of tumor necrosis factor-α-sensitized human airway smooth muscle cells

S Hu, L Wang, M Zheng, M Wang, B Chen… - Journal of Asthma, 2024 - Taylor & Francis
Abstract Objective: Protein kinase C (PKC) has been implicated in the increased contraction
of human airway smooth muscle cells (HASMCs) in asthma. Using the three-dimensional …

[HTML][HTML] New perspectives in pharmacological therapy for COPD: Phenotype classification and corticosteroids with bronchodilators

H Kume, R Yamada, Y Sato - A Compendium of Chronic …, 2022 - intechopen.com
Chronic obstructive lung disease (COPD) is heterogeneous and complex. Symptoms and
pathophysiological disorders overlap between COPD and asthma. To progress the …

[PDF][PDF] 补肺纳肾丸治疗慢性阻塞性肺疾病大鼠的效果及对肺组织ERK 1/2 的影响

闫文瑞, 张常喜, 平昕翀… - Journal of …, 2024 - elisa.oss-cn-shanghai.aliyuncs.com
目的探究补肺纳肾丸(BFNSP) 对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,
COPD) 大鼠模型的干预效果及对肺组织细胞外调节激酶(ERK 1/2) 表达的影响. 方法将38 …

The Genetic Epidemiology of Complex Lung Diseases

AC Wilson - 2023 - search.proquest.com
This research utilizes precision medicine techniques to advance our understanding of
Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) …