Dupilumab was first approved for the treatment of atopic dermatitis (AD) and blocks the
signaling of interleukin (IL)-4 and-13. Several other chronic skin conditions share …

Netherton syndrome (NS) is a rare and potentially life-threatening genetic skin disease
responsible for skin inflammation and scaling, hair abnormalities and severe allergic …

Inborn errors of immunity associated with atopy (IEIs-A) are a group of inherited monogenic
disorders that occur with immune dysregulation and frequent skin involvement. Several …

Abstract Background/Objectives Recent literature highlights the potential of biologics in the
management of inherited disorders of keratinisation. In this study, we conducted a …

Different monoclonal antibodies have been used for the treatment of Netherton's syndrome
(NS); secukinumab (anti-IL17A), infliximab (anti-TNF-α), ustekinumab (anti p40 subunit of IL …

We reported the case of a patient with Netherton syndrome (NS) who showed remarkable
cutaneous improvement using upadacitinib in the short term, but the efficacy decreased long …

Coloboma, congenital heart disease, ichthyosiform dermatosis, intellectual disability,
conductive hearing loss, and epilepsy (CHIME) syndrome is a rare autosomal recessive …

单基因遗传性皮肤病是一组临床罕见的疾病, 包括近1000 种表型不同的疾病.
通过全球皮肤学科及相关学科研究者的共同努力, 这些疾病的病因及发病机制研究在近30 …

Erythroderma indicates generalized erythema and scaling involving more than 80–90%
body surface area. There is a long list of differentials for neonatal and infantile erythroderma …