The cell microenvironment has a profound influence on the behaviour, growth and survival
of cells. The extracellular matrix (ECM) provides not only mechanical and structural support …

Abstract Aim Patients with Marfan syndrome have an increased risk of life-threatening aortic
complications, mostly preceded by aortic dilatation. Treatment with losartan, an angiotensin …

Marfan syndrome (MFS) is an inherited autosomal dominant multisystem disease caused by
mutations in the FBN1 gene encoding fibrillin-1, an extracellular matrix glycoprotein widely …

Calcium channel blockers (CCBs) are prescribed to patients with Marfan syndrome for
prophylaxis against aortic aneurysm progression, despite limited evidence for their efficacy …

Marfan syndrome (MFS) is an autosomal dominant disorder of the connective tissue
characterized by early development of thoracic aortic aneurysms/dissections together with …

Marfan syndrome (MFS) patients are at risk for cardiovascular disease. In particular, for
aortic aneurysm formation, which ultimately can result in a life-threatening aortic dissection …

Introduction: Marfan syndrome (MFS) is a connective tissue disorder with highly variable
features in cardiovascular, ocular and skeletal systems. MFS is generally caused by one of …

Aortic dilatation and aortic dissection are increasingly recognised in patients with Turner
syndrome (TS). Risk factors for aortic dissection include aortic dilatation, bicuspid aortic …

Two professional athletes in the US National Basketball Association required surgery for
aortic root dilation in 2012. These cases have attracted attention in sports medicine to the …

Aims Patients with Marfan syndrome have an increased risk of life-threatening aortic
complications, mostly preceded by aortic dilatation. In the FBN1 C1039G/+ Marfan mouse …