Animal models of diabetes mellitus

DA Rees, JC Alcolado - Diabetic medicine, 2005 - Wiley Online Library
Animal models have been used extensively in diabetes research. Early studies used
pancreatectomised dogs to confirm the central role of the pancreas in glucose homeostasis …

Maternal diabetes in pregnancy: early and long‐term outcomes on the offspring and the concept of “metabolic memory”

A Yessoufou, K Moutairou - Journal of Diabetes Research, 2011 - Wiley Online Library
The adverse outcomes on the offspring from maternal diabetes in pregnancy are
substantially documented. In this paper, we report main knowledge on impacts of maternal …

Revisiting human cholesterol synthesis and absorption: the reciprocity paradigm and its key regulators

PAS Alphonse, PJH Jones - Lipids, 2016 - Springer
Hypercholesterolemia is a major risk factor for cardiovascular disease. Cholesterol
homeostasis in the body is governed by the interplay between absorption, synthesis, and …

Chronic phase shifts of the photoperiod throughout pregnancy programs glucose intolerance and insulin resistance in the rat

TJ Varcoe, N Wight, A Voultsios, MD Salkeld… - PloS one, 2011 - journals.plos.org
Shift work during pregnancy is associated with an increased risk for preterm birth and low
birth weight. However, the impact upon the long term health of the children is currently …

Animal models for clinical and gestational diabetes: maternal and fetal outcomes

ACI Kiss, PHO Lima, YK Sinzato, M Takaku… - Diabetology & metabolic …, 2009 - Springer
Background Diabetes in pregnant women is associated with an increased risk of maternal
and neonatal morbidity and remains a significant medical challenge. Diabetes during …

Modulation of lipid metabolism by n−3 polyunsaturated fatty acids in gestational diabetic rats and their macrosomic offspring

NA Soulimane-Mokhtari, B Guermouche… - Clinical …, 2005 - portlandpress.com
The time course of changes in lipid metabolism by dietary n− 3 PUFAs (polyunsaturated fatty
acids) in streptozotocin-induced diabetic rats during pregnancy (days 12 and 21) and their …

N-3 fatty acids modulate antioxidant status in diabetic rats and their macrosomic offspring

A Yessoufou, N Soulaimann, SA Merzouk… - International Journal of …, 2006 - nature.com
Objective: We investigated the role of dietary n-3 polyunsaturated fatty acids (n-3 PUFA) in
the modulation of total antioxidant status in streptozotocin (STZ)-induced diabetic rats and …

Beneficial effects of omega‐3 polyunsaturated fatty acids in gestational diabetes: consequences in macrosomia and adulthood obesity

A Yessoufou, MP Nekoua, A Gbankoto… - Journal of diabetes …, 2015 - Wiley Online Library
Omega‐3 polyunsaturated fatty acids (PUFAs) are increasingly being used to prevent
cardiovascular diseases, including diabetes and obesity. In this paper, we report data on the …

Implication of lipids in macrosomia of diabetic pregnancy: can n-3 polyunsaturated fatty acids exert beneficial effects?

H Merzouk, NA Khan - Clinical Science, 2003 - portlandpress.com
Macrosomia or fetal obesity is a frequent complication of pregnancy in diabetes mellitus.
Several alterations observed in carbohydrate and lipid metabolism in macrosomic infants of …

Repercussions of mild diabetes on pregnancy in Wistar rats and on the fetal development

FH Saito, DC Damasceno, WG Kempinas… - Diabetology & Metabolic …, 2010 - Springer
Background Experimental models are necessary to elucidate diabetes pathophysiological
mechanisms not yet understood in humans. Objective: To evaluate the repercussions of the …