The formation of new blood vessels, called angiogenesis, is an essential pathophysiological
process in which several families of regulators have been implicated. Among these, vascular …

The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Globally, clear-cell renal cell carcinoma (ccRCC) represents the most prevalent type of
kidney cancer. Surgery plays a key role in the treatment of this cancer, although one third of …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

The last 50 years have witnessed extraordinary developments in understanding
mechanisms of carcinogenesis, synthesized as the hallmarks of cancer. Despite this logical …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Macrophages, as pivotal cells within the tumour microenvironment, significantly influence
the impact of and reactions to treatments for solid tumours. The rapid evolution of …

The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has
given rise to the prominence of the tumor microenvironment (TME) as a critical area of …

IκBζ (encoded by NFKBIZ) is the most recently identified IkappaB family protein. As an
atypical member of the IkappaB protein family, NFKBIZ has been the focus of recent studies …