In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …

Uterine aging is an important factor that impacts fertility, reproductive health, and uterus-
related diseases; however, it remains poorly explored. Functionally, these disturbances …

Advanced maternal age (AMA) pregnancies are rapidly increasing and are associated with
aberrant trophoblast cell function, poor placentation, and unfavorable pregnancy outcomes …

Aims/hypothesis Assisted reproductive technology (ART) is the most widely used treatment
for infertility and has resulted in millions of births worldwide. The safety of the offspring has …

Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the
gut. Recent advances in metagenomics and metabolomics have revealed that the gut …

Purpose Fertility at advanced age has become increasingly common, but the aging of
parents may adversely affect the maturation of gametes and the development of embryos …

Advanced maternal age (AMA) pregnancy is associated with higher risks of adverse
perinatal outcomes, which may result from premature senescence of the placenta. α‐Klotho …

The decision to postpone parenting has gained momentum in recent years, a shift driven by
evolving social dynamics and improved access to fertility treatments. Despite their …

Cellular senescence (CS) is defined as a state of terminal proliferation arrest accompanied
by morphological alterations, pro-inflammatory phenotype, and metabolic changes. In recent …

Advanced maternal age (≥ 35 years) is associated with pregnancy complications. Aging
impairs vascular reactivity and increases vascular stiffness. We hypothesized that uterine …