ABSTRACT The 'Antibodies to Watch'article series provides an annual summary of
commercially sponsored monoclonal antibody therapeutics currently in late-stage clinical …

Hereditary angioedema (HAE) is a rare disease characterized by sudden and often
unprovoked episodes of swelling that can be potentially life-threatening when it involves the …

Hereditary angioedema (HAE) is a rare autosomal dominant disease, with patients often
suffering with associated symptoms for many years before receiving a correct diagnosis. The …

Background Approved on-demand treatments for hereditary angioedema attacks need to be
administered parenterally, a route of administration that is associated with delays in …

Hereditary angioedema is a potentially life-threatening autosomal dominant condition,
causing attacks of angioedema due to failure to regulate bradykinin. Nearly all cases of …

Background: The kallikrein kinin system (KKS) is an established pharmacological target for
the treatment and prevention of attacks in hereditary angioedema (HAE). Proteolytic …

Cold urticaria is a chronic condition causing episodic symptoms of cold-induced wheals or
angioedema in response to direct or indirect exposure to cold temperatures. Whereas …

Abstract C1 inhibitor (C1Inh) is a serine protease inhibitor involved in the kallikrein-kinin
system, the complement system, the coagulation system, and the fibrinolytic system. In …

Introduction Hereditary angioedema (HAE) is a rare genetic disorder characterized by
recurrent edema and predominantly caused by the dysregulation of the kinin-kallikrein …

Hereditary angioedema (HAE) is typically caused by a deficiency of the protease inhibitor
C1 inhibitor (C1INH). The absence of C1INH activity on plasma kallikrein and factor XIIa …