Current research into Parkinson's disease (PD) is directed at developing novel agents and
strategies for improved symptomatic management. The aim of this research is to provide …

Parkinson's disease (PD) often manifests with prodromal pain and sensory losses whose
etiologies are not well understood. Multiple genetic and toxicity-based rodent models of PD …

The rhesus macaque (Macaca mulatta) is the most utilized primate model in the biomedical
and psychological sciences. Expressive behavior is of interest to scientists studying these …

Parkinson's disease pathogenesis proceeds through several phases, culminating in the loss
of dopaminergic neurons of the substantia nigra (SN). Although the 1-methyl-4-phenyl-1, 2 …

Recent research is leading to an ever-increasing range of investigative approaches whose
aim is to achieve effective neuroprotective or neurorestorative treatment for individuals …

In order to model various aspects of Huntington's disease (HD) pathology, in particular
protein spread, we administered adeno-associated virus (AAV) expressing green …

Through bioinformatics analyses of a human gene expression database representing 105
different tissues and cell types, we identified 687 skin-associated genes that are selectively …

In recent years, substantial evidence has emerged to suggest that spreading of pathological
proteins contributes to disease pathology in numerous neurodegenerative disorders. Work …

INTRODUCTION: The objective of this study was to establish a functional observational
battery that provided a basic neurological and behavioral assessment fully compliant with …

The aim of this paper is to offer an ethical perspective on the use of non-human primates in
neurobiological studies, using the Parkinson's disease (PD) as an important case study. We …