The evolutionary diversification of LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages
Background The transcription factors of the LSF/Grainyhead (GRH) family are characterized
by the possession of a distinctive DNA-binding domain that bears no clear relationship to …
by the possession of a distinctive DNA-binding domain that bears no clear relationship to …
TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer
Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic
landscape associated with cancer, with a minimal number of genes exhibiting dual-context …
landscape associated with cancer, with a minimal number of genes exhibiting dual-context …
LSF and NTF-1 share a conserved DNA recognition motif yet require different oligomerization states to form a stable protein-DNA complex
MK Shirra, U Hansen - Journal of Biological Chemistry, 1998 - ASBMB
The mammalian transcription factor LSF (also known as CP2 and LBP-1c) binds as a homo-
oligomer to directly repeated elements in viral and cellular promoters. LSF and …
oligomer to directly repeated elements in viral and cellular promoters. LSF and …
Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway
TR Burton, A Dibrov, T Kashour, FM Amara - Molecular brain research, 2002 - Elsevier
Alzheimer amyloid precursor protein (APP) effectively protects against apoptosis in neuronal
cells under stress, but the mechanisms of this anti-apoptotic effect remain largely unknown …
cells under stress, but the mechanisms of this anti-apoptotic effect remain largely unknown …
[HTML][HTML] Late SV40 factor: a key mediator of Notch signaling in human hepatocarcinogenesis
RH Fan, J Li, N Wu, PS Chen - World journal of gastroenterology …, 2011 - ncbi.nlm.nih.gov
AIM: To investigate the relationship between late SV40 factor (LSF) and Notch signaling in
the development and progress of hepatocellular carcinoma (HCC). METHODS: Liver cancer …
the development and progress of hepatocellular carcinoma (HCC). METHODS: Liver cancer …
Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors
A Tuckfield, DR Clouston, TM Wilanowski… - … and cellular biology, 2002 - Am Soc Microbiol
Abstract The Polycomb group (PcG) of proteins represses homeotic gene expression
through the assembly of multiprotein complexes on key regulatory elements. The …
through the assembly of multiprotein complexes on key regulatory elements. The …
Transcription factors LSF and E2Fs: tandem cyclists driving G0 to S?
U Hansen, L Owens, U Saxena - Cell Cycle, 2009 - Taylor & Francis
Cell cycle progression in mammalian cells from G1 into S phase requires sensing and
integration of multiple inputs, in order to determine whether to continue to cellular DNA …
integration of multiple inputs, in order to determine whether to continue to cellular DNA …
[HTML][HTML] Transcription factor LSF (TFCP2) inhibits melanoma growth
Y Goto, I Yajima, M Kumasaka, N Ohgami, A Tanaka… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract Late SV40 factor 3 (LSF), a transcription factor, contributes to human hepatocellular
carcinoma (HCC). However, decreased expression level of LSF in skin melanoma …
carcinoma (HCC). However, decreased expression level of LSF in skin melanoma …
[HTML][HTML] Regulation of the g1/s transition in hepatocytes: involvement of the cyclin-dependent kinase cdk1 in the DNA replication
A Corlu, P Loyer - International Journal of Hepatology, 2012 - ncbi.nlm.nih.gov
A singular feature of adult differentiated hepatocytes is their capacity to proliferate allowing
liver regeneration. This review emphasizes the literature published over the last 20 years …
liver regeneration. This review emphasizes the literature published over the last 20 years …
Defective extraembryonic angiogenesis in mice lacking LBP-1a, a member of the grainyhead family of transcription factors
LBP-1a and CP2 are ubiquitously expressed members of the grainyhead transcription factor
family, sharing significant sequence homology, a common DNA binding motif, and …
family, sharing significant sequence homology, a common DNA binding motif, and …