The biology of the intestinal intracellular parasite Cryptosporidium
A Guérin, B Striepen - Cell host & microbe, 2020 - cell.com
Cryptosporidium emerged as a leading global cause of severe diarrheal disease in children.
The parasite occupies a unique intracellular niche at the brush border of intestinal epithelial …
The parasite occupies a unique intracellular niche at the brush border of intestinal epithelial …
Cryptosporidiosis: from prevention to treatment, a narrative review
Cryptosporidiosis is a water-and food-borne zoonotic disease caused by the protozoon
parasite of the genus Cryptosporidium. C. hominis and C. parvum are the main two species …
parasite of the genus Cryptosporidium. C. hominis and C. parvum are the main two species …
Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell
Cryptosporidium is a leading cause of diarrheal disease in children and an important
contributor to early childhood mortality. The parasite invades and extensively remodels …
contributor to early childhood mortality. The parasite invades and extensively remodels …
Immunity to Cryptosporidium: insights into principles of enteric responses to infection
Cryptosporidium parasites replicate within intestinal epithelial cells and are an important
cause of diarrhoeal disease in young children and in patients with primary and acquired …
cause of diarrhoeal disease in young children and in patients with primary and acquired …
Genetic crosses within and between species of Cryptosporidium
Parasites and their hosts are engaged in reciprocal coevolution that balances competing
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …
Commensal Cryptosporidium colonization elicits a cDC1-dependent Th1 response that promotes intestinal homeostasis and limits other infections
EV Russler-Germain, J Jung, AT Miller, S Young, J Yi… - Immunity, 2021 - cell.com
Cryptosporidium can cause severe diarrhea and morbidity, but many infections are
asymptomatic. Here, we studied the immune response to a commensal strain of …
asymptomatic. Here, we studied the immune response to a commensal strain of …
Cryptosporidium uses CSpV1 to activate host type I interferon and attenuate antiparasitic defenses
Cryptosporidium infects gastrointestinal epithelium and is a leading cause of infectious
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
diarrhea and diarrheal-related death in children worldwide. There are no vaccines and no …
Expansion microscopy of apicomplexan parasites
Apicomplexan parasites comprise significant pathogens of humans, livestock and wildlife,
but also represent a diverse group of eukaryotes with interesting and unique cell biology …
but also represent a diverse group of eukaryotes with interesting and unique cell biology …
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum
R Xu, WL Beatty, V Greigert, WH Witola… - Nature …, 2024 - nature.com
Cryptosporidium parvum is an obligate intracellular parasite with a highly reduced
mitochondrion that lacks the tricarboxylic acid cycle and the ability to generate ATP, making …
mitochondrion that lacks the tricarboxylic acid cycle and the ability to generate ATP, making …
Division and transmission: malaria parasite development in the mosquito
DS Guttery, M Zeeshan, DJP Ferguson… - Annual Review of …, 2022 - annualreviews.org
The malaria parasite life cycle alternates between two hosts: a vertebrate and the female
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …
Anopheles mosquito vector. Cell division, proliferation, and invasion are essential for …