The complement is a powerful cascade of the innate immunity and also acts as a bridge
between innate and acquired immune defence. Complement activation can occur via three …

Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes
generated in the C3 and C5 convertases of the complement system, causing its …

The overall diagnostic yield of massively parallel sequencing–based tests in patients with
chronic kidney disease (CKD) is 30% for paediatric cases and 6–30% for adult cases. These …

Introduction Complement 3 glomerulopathy (C3G) is a rare kidney disease characterized by
dysregulation of the alternative pathway (AP) of the complement system. About 50% of …

Introduction Dysregulated complement activation is likely the primary driver of disease in C3
glomerulopathy (C3G) and contributes to other complement-mediated diseases, including …

Rationale & Objective Primary membranoproliferative glomerulonephritis (MPGN) is a rare
glomerulopathy characterized by complement dysregulation. MPGN progresses rapidly to …

Recently, the comprehensive concept of “infection-related glomerulonephritis (IRGN)” has
replaced that of postinfectious glomerulonephritis (PIGN) because of the diverse infection …

The potential of collagens to release biopeptides was evaluated using the BIOPEP-UWM-
implemented quantitative criteria including the frequency of the release of fragments with a …

Complement is an evolutionarily conserved system which is important in the defense against
microorganisms and also in the elimination of modified or necrotic elements of the body …

Background Primary membranoproliferative GN, including complement 3 (C3)
glomerulopathy, is a rare, untreatable kidney disease characterized by glomerular …