Molecular mechanisms of cervical carcinogenesis by high‐risk human papillomaviruses: novel functions of E6 and E7 oncoproteins

T Yugawa, T Kiyono - Reviews in medical virology, 2009 - Wiley Online Library
Over the last two decades, since the initial discovery of human papillomavirus (HPV) type 16
and 18 DNAs in cervical cancers by Dr. Harald zur Hausen (winner of the Nobel Prize in …

Estrogen and its receptors in cancer

GG Chen, Q Zeng, GMK Tse - Medicinal research reviews, 2008 - Wiley Online Library
The involvement of estrogen and its receptors in the development of cancer has been known
for years. However, the exact mechanism responsible is far from clear. The estrogen …

Molecular transitions from papillomavirus infection to cervical precancer and cancer: Role of stromal estrogen receptor signaling

JA Den Boon, D Pyeon, SS Wang… - Proceedings of the …, 2015 - National Acad Sciences
To study the multistep process of cervical cancer development, we analyzed 128 frozen
cervical samples spanning normalcy, increasingly severe cervical intraepithelial neoplasia …

[图书][B] Human papillomaviruses

IARC Working Group on the Evaluation of … - 2007 - books.google.com
This ninetieth volume of the IARC Monographs on the Evaluation of Carcinogenic Risks to
Humansconsiders human papillomaviruses (HPVs) which were evaluated by a previous …

The immune microenvironment in human papilloma virus-induced cervical lesions—Evidence for estrogen as an immunomodulator

J Rs - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
Globally, human papilloma virus (HPV) infection is a common sexually transmitted disease.
However, most of the HPV infections eventually resolve aided by the body's efficient cell …

Validating cancer drug targets

JD Benson, YNP Chen, SA Cornell-Kennon, M Dorsch… - Nature, 2006 - nature.com
A cancer drug target is only truly validated by demonstrating that a given therapeutic agent is
clinically effective and acts through the target against which it was designed. Nevertheless, it …

Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells

GP Williams, PD Darbre - Molecular and cellular endocrinology, 2019 - Elsevier
Background Phenolic endocrine-disrupting compounds (EDCs) have long been suspected
of increasing human breast cancer risk, via aromatase up-regulation; however, the …

Recent changes among human influenza viruses

YP Lin, V Gregory, M Bennett, A Hay - Virus research, 2004 - Elsevier
Recurrent epidemics of influenza are due to the frequent emergence of antigenic variants.
With co-circulation of two influenza A subtypes and two antigenically distinct lineages of B …

Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation

A Suksamrarn, M Ponglikitmongkol… - Bioorganic & medicinal …, 2008 - Elsevier
Three new diarylheptanoids, a 1: 2 mixture of (3S)-and (3R)-1-(4-methoxyphenyl)-7-phenyl-
(6E)-6-hepten-3-ol (13a and 13b) and 1-(4-hydroxyphenyl)-7-phenyl-(6E)-6-hepten-3-one …

A study on the correlation between the prognosis of HPV infection and lesion recurrence after cervical conization

J Lu, S Han, Y Li, J Na, J Wang - Frontiers in Microbiology, 2023 - frontiersin.org
Introduction Persistent human papillomavirus infection is an important factor in the
development of cervical cancer, which is usually a long process evolving from the …