Background: Atrial fibrillation is a strong independent risk factor for stroke. Purpose: To
characterize the efficacy and safety of antithrombotic agents for stroke prevention in patients …

The aims of severe perioperative bleeding management are three-fold. First, preoperative
identification by anamesis and laboratory testing of those patients for whom the …

Background Patients with atrial fibrillation (AF) often require anticoagulation and platelet
inhibition, but data are limited on the bleeding risk of combination therapy. Methods We …

This article concerning the pharmacokinetics and pharmacodynamics of vitamin K
antagonists (VKAs) is part of the American College of Chest Physicians Evidence-Based …

For new or updated text, view the 2011 Focused Update and the 2011 Focused Update on
Dabigatran. Text supporting unchanged recommendations has not been updated. Atrial …

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, increasing
in prevalence with age. AF is often associated with structural heart disease, although a …

Background—Warfarin is effective in the prevention of stroke in atrial fibrillation but is under
used in clinical care. Concerns exist that published rates of hemorrhage may not reflect real …

Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance, increasing
in prevalence with age. AF is often associated with structural heart disease, although a …

BACKGROUND: Atrial fibrillation (AF) affects a significant proportion of the American
population and increases ischemic stroke risk by 4-to 5-fold. Oral vitamin K antagonists …

Background—Pharmacogenetic-guided dosing of warfarin is a promising application of
“personalized medicine” but has not been adequately tested in randomized trials. Methods …