In most daily activities related to work or leisure, the energy for muscle work substantially
comes from oxidative metabolism. Functional limitations or impairments of this metabolism …

The near-infrared radiation (NIR) window, also known as the “optical window” or
“therapeutic window”, is the range of wavelengths that has the maximum depth of …

The aim of this study was to investigate local muscle O2consumption (muscV˙ o 2) and
forearm blood flow (FBF) in resting and exercising muscle by use of near-infrared …

Near-infrared spectroscopy (NIRS) was initiated in 1977 by Jobsis as a simple, noninvasive
method for measuring the presence of oxygen in muscle and other tissues in vivo. This …

Impaired skeletal muscle oxidative phosphorylation in patients with severe mitochondrial
respiratory chain defects results in disabling exercise intolerance that is associated with a …

Oxidative metabolism is the dominant source of energy for skeletal muscle. Near–infrared
spectroscopy allows the non–invasive measurement of local oxygenation, blood flow and …

This review is devoted to the molecular genetics and bioenergetics of human mitochondria
related to the mechanism of aging. Morphological and functional changes of mitochondria …

The authors introduce a simple method to characterize optical properties and blood
oxygenation in tissue using spatially resolved, steady-state reflectance. The method …

Objective Susceptibility to exertional cramps and rhabdomyolysis in myophosphorylase
deficiency (McArdle's disease [MD]) may lead patients to shun exercise. However, physical …

Background Blocked glycogen breakdown in McArdle disease impairs oxidative as well as
anaerobic metabolism, but the contribution of impaired oxidative phosphorylation to …