The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …

Several monoclonal antibodies are now approved for cancer therapy, such as rituximab, an
anti-CD20 monoclonal antibody for the treatment of B-cell non-Hodgkin's lymphoma …

The use of “non-standard” metallic radionuclides continues to be an expanding field of
investigation. Radiolabeling small molecules, peptides, proteins, and up to nano-particles …

A simple and rapid procedure was developed for purification of cyclotron produced 86Y via
the 86Sr (p, n) 86Y reaction. A commercially available Sr (II) selective resin was used to …

The studies reported herein present the first in vitro and in vivo comparison of
radioimmunoconjugates (RIC) radiolabeled with 177Lu using the acyclic CHX-A ″-DTPA …

Treatment of patients with therapeutic monoclonal antibodies (mAbs) such as rituximab
(Rituxan), an anti-CD20 mAb, or trastuzumab (Herceptin), an anti-HER2 mAb, have shown …

This review will discuss the production and applications of positron-emitting radionuclides
for use in Positron Emission Tomography (PET), with emphasis on radionuclides that can be …

Detailed synthesis of the bifunctional chelating agents 2-methyl-6-(p-isothiocyanatobenzyl)-
1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (1B4M-DOTA) and 2-(p …

Within the emerging field of medicinal inorganic chemistry, the realization that metal
complexes can be designed as both therapeutic and diagnostic agents with novel …

Metal coordination of bioorganic compounds from both natural and synthetic products is not
only gaining recognition in drug design and medicinal inorganic chemistry research, also …