Diabetic retinopathy (DR) affects over 93 million people worldwide and is the number one
cause of blindness among working age adults. These indicators coupled with the projected …

Diabetic retinopathy (DR) is one of the major complications of diabetes. Although great
efforts have been made to uncover the mechanisms underlying the pathology of DR, the …

Purpose Increased oxidative stress and inflammatory mediators are implicated in the
development of diabetic retinopathy, and in rats, its development can be prevented by …

Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

Objective The vasodegenerative phase of diabetic retinopathy is characterized by not only
retinal vascular degeneration but also inadequate vascular repair due to compromised bone …

Elovl4 is a fatty acyl elongase that participates in the biosynthesis of very long-chain fatty
acids (≥ C24), which are relatively abundant in skin (saturated chains), or retina, brain and …

The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and
ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular …

Neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and
age-related macular degeneration, threaten the visual health of children and adults. Current …

Rare, nondietary very-long-chain polyunsaturated fatty acids (VLC-PUFAs) are uniquely
found in the retina and a few other vertebrate tissues. These special fatty acids play a …

Long-chain PUFAs (LC-PUFAs; C20–C22; eg, DHA and arachidonic acid) are highly
enriched in vertebrate retina, where they are elongated to very-long-chain PUFAs (VLC …