Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

MicroRNAs in cancer and cardiovascular disease

M Ilieva, R Panella, S Uchida - Cells, 2022 - mdpi.com
Although cardiac tumor formation is rare, accumulating evidence suggests that the two
leading causes of deaths, cancers, and cardiovascular diseases are similar in terms of …

Exosomal miR-27b-3p secreted by visceral adipocytes contributes to endothelial inflammation and atherogenesis

Y Tang, LJ Yang, H Liu, YJ Song, QQ Yang, Y Liu… - Cell reports, 2023 - cell.com
Obesity, particularly increased visceral fat, positively correlates with various metabolic
challenges, including atherosclerosis, but the mechanism is not fully understood. The aim of …

Exosomal microRNAs in milk from mothers delivering preterm infants survive in vitro digestion and are taken up by human intestinal cells

S Kahn, Y Liao, X Du, W Xu, J Li… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope This study investigates the ability of preterm milk exosomes to survive
gastric/pancreatic digestion, internalization by intestinal epithelia, and the microRNAs …

LncRNA H19 ameliorates myocardial infarction‐induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A

B Zhang, H Jiang, J Chen, Q Hu… - Journal of cellular …, 2020 - Wiley Online Library
Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide,
and novel therapeutic targets still need to be investigated to alleviate myocardial injury and …

[HTML][HTML] Non-coding RNAs as biomarkers of myocardial infarction

H Almaghrbi, R Giordo, G Pintus, H Zayed - Clinica Chimica Acta, 2023 - Elsevier
Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack
protein-coding potential and have tissue-specific expression. A significant body of evidence …

Function and therapeutic potential of noncoding RNAs in cardiac fibrosis

EE Creemers, E Van Rooij - Circulation research, 2016 - Am Heart Assoc
Cardiac fibrosis as a result of excessive extracellular matrix deposition leads to stiffening of
the heart, which can eventually lead to heart failure. An important event in cardiac fibrosis is …

Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women

S Novella, D Pérez‐Cremades… - The Journal of …, 2019 - Wiley Online Library
Women show a lower incidence of cardiovascular diseases than age‐matched men, but this
benefit disappears after menopause. Oestrogen‐mediated vascular actions are mainly …

Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function

JK Du, BH Cong, Q Yu, H Wang, L Wang… - Free Radical Biology …, 2016 - Elsevier
Mitochondrial oxidative damage is critically involved in cardiac ischemia reperfusion (I/R)
injury. MicroRNA-22 (miR-22) has been predicted to potentially target sirtuin-1 (Sirt1) and …

Clinical significance of MicroRNAs, long non-coding RNAs, and CircRNAs in cardiovascular diseases

DD Singh, Y Kim, SA Choi, I Han, DK Yadav - Cells, 2023 - mdpi.com
Based on recent research, the non-coding genome is essential for controlling genes and
genetic programming during development, as well as for health and cardiovascular …