Radiologically isolated syndromes: to treat or not to treat?

P Preziosa, MA Rocca, M Filippi - Journal of Neurology, 2024 - Springer
The widespread use of magnetic resonance imaging (MRI) has led to increased detection of
individuals exhibiting asymptomatic brain and spinal cord lesions suggestive of multiple …

Radiologically isolated syndrome in the spectrum of multiple sclerosis

DT Okuda, C Lebrun-Frénay - Multiple Sclerosis Journal, 2024 - journals.sagepub.com
The radiologically isolated syndrome (RIS) currently represents the earliest detectable
preclinical phase of multiple sclerosis (MS). Remarkable advancements have been recently …

Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis

MA Rocca, P Preziosa, F Barkhof… - The Lancet Regional …, 2024 - thelancet.com
In the majority of cases, multiple sclerosis (MS) is characterized by reversible episodes of
neurological dysfunction, often followed by irreversible clinical disability. Accurate diagnostic …

A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis

L Daboul, CM O'Donnell, M Amin… - Multiple Sclerosis …, 2024 - journals.sagepub.com
Background: The central vein sign (CVS) is a proposed magnetic resonance imaging (MRI)
biomarker for multiple sclerosis (MS); the optimal method for abbreviated CVS scoring is not …

Laboratory Diagnosis of Intrathecal Synthesis of Immunoglobulins: A Review about the Contribution of OCBs and K-index

M Morello, S Mastrogiovanni, F Falcione… - International Journal of …, 2024 - mdpi.com
The diagnosis of MS relies on a combination of imaging, clinical examinations, and
biological analyses, including blood and cerebrospinal fluid (CSF) assessments. G …

Circulating MAIT cells in multiple sclerosis and amyotrophic lateral sclerosis

D De Federicis, C Bassani, RR Chiarelli… - Frontiers in …, 2024 - frontiersin.org
Neurological disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis
(ALS), may be associated with alterations in blood cell composition and phenotype. Here …

Multiple sclerosis can be diagnosed solely with dissemination in space: No.

CC Hemond, AJ Solomon - Multiple Sclerosis Journal, 2024 - search.ebscohost.com
The article discusses the concept of" dissemination in time"(DIT) in the diagnosis of multiple
sclerosis (MS). DIT has been a key component of MS diagnosis for decades, helping to …

Moving towards a new era for the treatment of neuromyelitis optica spectrum disorders

P Preziosa, MP Amato, L Battistini, M Capobianco… - Journal of …, 2024 - Springer
Neuromyelitis optica spectrum disorders (NMOSD) include a rare group of autoimmune
conditions that primarily affect the central nervous system. They are characterized by …

Laboratory evaluation for the differential diagnosis of possible multiple sclerosis in the United States: A physician survey

R Mustafa, EP Flanagan, DJ Duffy… - Journal of the …, 2023 - Elsevier
Background There is limited evidence and lack of guidelines for diagnostic laboratory
evaluation of patients with possible multiple sclerosis (MS). Objective To survey neurologists …

[HTML][HTML] Kynurenines and Inflammation: A Remarkable Axis for Multiple Sclerosis Treatment

P Carrillo-Mora, C Landa-Solís, D Valle-Garcia… - Pharmaceuticals, 2024 - mdpi.com
Multiple sclerosis (MS) is a chronic inflammatory autoimmune neurological disease
characterized by the recurrent appearance of demyelinating lesions and progressive …