[HTML][HTML] Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

[HTML][HTML] Adaptive immunity: an emerging player in the progression of NAFLD

S Sutti, E Albano - Nature Reviews Gastroenterology & Hepatology, 2020 - nature.com
In the past decade, nonalcoholic fatty liver disease (NAFLD) has become a leading cause of
chronic liver disease and cirrhosis, as well as an important risk factor for hepatocellular …

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

JP Arab, M Arrese, M Trauner - Annual Review of Pathology …, 2018 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

[HTML][HTML] FGF21: an emerging therapeutic target for non-alcoholic steatohepatitis and related metabolic diseases

EJ Tillman, T Rolph - Frontiers in endocrinology, 2020 - frontiersin.org
The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Effects of melatonin on fatty liver disease: The role of NR 4A1/DNA‐PK cs/p53 pathway, mitochondrial fission, and mitophagy

H Zhou, W Du, YE Li, C Shi, N Hu, S Ma… - Journal of pineal …, 2018 - Wiley Online Library
Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

G Svegliati-Baroni, I Pierantonelli, P Torquato… - Free Radical Biology …, 2019 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver
disease worldwide (about 25% of the general population) and 3–5% of patients develop non …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

[HTML][HTML] The role of oxidative stress in NAFLD–NASH–HCC transition—focus on NADPH oxidases

D Gabbia, L Cannella, S De Martin - Biomedicines, 2021 - mdpi.com
A peculiar role for oxidative stress in non-alcoholic fatty liver disease (NAFLD) and its
transition to the inflammatory complication non-alcoholic steatohepatitis (NASH), as well as …

Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

M Gliozzi, V Musolino, F Bosco, M Scicchitano… - Pharmacological …, 2021 - Elsevier
Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

[HTML][HTML] Lipotoxicity as the leading cause of non-alcoholic steatohepatitis

M Branković, I Jovanović, M Dukić, T Radonjić… - International Journal of …, 2022 - mdpi.com
The emerging issues nowadays are non-alcoholic fatty liver disease (NAFLD) and its
advanced stage non-alcoholic steatohepatitis (NASH), which further can be a predisposing …