Histopathologic examination reveals that most human tumors are associated with diverse
immune cell infiltrates, but the roles of host reactions in disease pathogenesis and prognosis …

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …

The activating natural killer group 2 member D (NKG 2 D) receptor is expressed on NK cells,
cytotoxic T cells and additional T cell subsets. Ligands for human NKG 2 D comprise two …

Background Diffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for
insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in …

Background Digestive malignancies, especially pancreatic cancer (PC), gastric cancer (GC),
and colorectal cancer (CRC), still occur at persistently high rates, and disease progression …

Simple Summary Immune surveillance during periods of cellular stress is necessary to
maintain homeostasis. In distressed cells, the expression of stress (natural killer group 2 …

Purpose: STAT3 is a transcription factor that is constitutively activated in some cancers. It
seems to play crucial roles in cell proliferation and survival, angiogenesis, tumor-promoting …

NK cell exhaustion is caused by chronic exposure to activating stimuli during viral infection,
tumorigenesis, and prolonged cytokine treatment. Evidence suggests that exhaustion may …

Human and mouse NKG 2D ligands (NKG 2 DL s) are absent or only poorly expressed by
most normal cells but are upregulated by cell stress, hence, alerting the immune system in …

Objective To evaluate immunosurveillance/editing in colorectal cancer. Design
Transformation stimulates the production of interferon γ (IFNγ) which signals via the IFNγ …