Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Oxidative stress is closely related to the physiopathology of numerous diseases. Reactive
oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS) …

Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Reperfusion injury is still a major challenge that impedes neuronal survival in ischemic
stroke. However, the current clinical treatments are remained on single pathological …

The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …