Use of intramuscular triacylglycerol as a substrate source during exercise in humans

LJC van Loon - Journal of applied physiology, 2004 - journals.physiology.org
Fat and carbohydrate are the principal substrates that fuel aerobic ATP synthesis in skeletal
muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral …

The effects of exercise on the storage and oxidation of dietary fat

K Hansen, T Shriver, D Schoeller - Sports medicine, 2005 - Springer
Obesity has become a worldwide problem of pandemic proportions. By definition, obesity is
the accumulation of excess body fat and it represents the long-term results of positive energy …

Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance‐trained males in a fasted state

LJC Van Loon, R Koopman… - The Journal of …, 2003 - Wiley Online Library
Both stable isotope methodology and fluorescence microscopy were applied to define the
use of intramuscular triglyceride (IMTG) stores as a substrate source during exercise on a …

Human skeletal muscle fatty acid and glycerol metabolism during rest, exercise and recovery

G Van Hall, M Sacchetti, G Rådegran… - The Journal of …, 2002 - Wiley Online Library
This study was conducted to investigate skeletal muscle fatty acid (FA) and glycerol kinetics
and to determine the contribution of skeletal muscle to whole body FA and glycerol turnover …

Combined effects of a ketogenic diet and exercise training alter mitochondrial and peroxisomal substrate oxidative capacity in skeletal muscle

TY Huang, MA Linden, SE Fuller… - American Journal …, 2021 - journals.physiology.org
Ketogenic diets (KDs) are reported to improve body weight, fat mass, and exercise
performance in humans. Unfortunately, most rodent studies have used a low-protein KD …

IMCL area density, but not IMCL utilization, is higher in women during moderate-intensity endurance exercise, compared with men

MC Devries, SA Lowther, AW Glover… - American Journal …, 2007 - journals.physiology.org
Women use more fat during endurance exercise as evidenced by a lower respiratory
exchange ratio (RER). The contribution of intramyocellular lipid (IMCL) to lipid oxidation …

Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics

MB Krag, LC Gormsen, ZK Guo… - American Journal …, 2007 - journals.physiology.org
The ability of growth hormone (GH) to stimulate lipolysis and cause insulin resistance in
skeletal muscle may be causally linked, but the mechanisms remain obscure. We …

Age-Related Changes in Intramyocellular Lipid in Humans by in vivo 1H-MR Spectroscopy

Y Nakagawa, M Hattori, K Harada, R Shirase, M Bando… - Gerontology, 2007 - karger.com
Background: It is considered that the increasing intramyocellular lipid (IMCL) affects health
risks and muscle attenuation. Though body fat increases significantly with age in lean …

High triacylglycerol turnover rate in human skeletal muscle

M Sacchetti, B Saltin, DB Olsen… - The Journal of …, 2004 - Wiley Online Library
In the present study we investigated the relationship between plasma fatty acids (FA) and
intramuscular triacylglycerol (IMTAG) kinetics of healthy volunteers. With this aim [U‐13C] …

Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

SJ Lessard, SLL Giudice, W Lau, JJ Reid… - …, 2004 - academic.oup.com
We hypothesized that improved glucose tolerance with rosiglitazone treatment would
coincide with decreased levels of im triacylglycerol (IMTG), diacylglycerol, and ceramide …