S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to
play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the …

Cartilage oligomeric matrix protein (COMP) is a large pentameric glycoprotein that interacts
with multiple extracellular matrix proteins in cartilage and other tissues. While, COMP is …

Calprotectin is a heterodimer formed by two proteins, S100A8 and S100A9, which are
mainly produced by activated monocytes and neutrophils in the circulation and in inflamed …

Rheumatic diseases are characterized by sterile inflammation that causes severe long-term
damage to various organ systems. A growing body of evidence supports a pivotal role for the …

Interstitial lung disease (ILD) is common in systemic sclerosis (SSc) patients and despite
recent advances in the treatment is, at present, the major cause of death. Today, an early …

Background Interstitial lung disease (ILD) is the most common cause of death in patients
with systemic sclerosis (SSc). Prognostic biomarkers are needed to identify SSc-ILD patients …

Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins,
S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and …

Objective To investigate the relationship between Krebs von den Lungen 6 (KL‐6) and CCL
18 levels and the severity and progression of systemic sclerosis (SS c)–related interstitial …

Systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) are two phenotypically
distincts inflammatory systemic diseases. However, SLE and SSc share pathogenic features …

Exaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs) are
reported in systemic sclerosis (SSc) but its involvement in SSc pathogenesis is not clear. In …