Pregnancy-associated liver diseases

NA Terrault, C Williamson - Gastroenterology, 2022 - Elsevier
The liver disorders unique to pregnancy include hyperemesis gravidarum, intrahepatic
cholestasis of pregnancy, acute fatty liver of pregnancy, and preeclampsia-associated …

EASL Clinical Practice Guidelines on sclerosing cholangitis

O Chazouilleres, U Beuers, A Bergquist, TH Karlsen… - Journal of …, 2022 - Elsevier
Management of primary or secondary sclerosing cholangitis is challenging. These Clinical
Practice Guidelines have been developed to provide practical guidance on debated topics …

[HTML][HTML] Importance of fatigue and its measurement in chronic liver disease

LH Gerber, AA Weinstein, R Mehta… - World journal of …, 2019 - ncbi.nlm.nih.gov
The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and
non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue …

The potential function and clinical application of FGF21 in metabolic diseases

Z Chen, L Yang, Y Liu, P Huang, H Song… - Frontiers in …, 2022 - frontiersin.org
As an endocrine hormone, fibroblast growth factor 21 (FGF21) plays a crucial role in
regulating lipid, glucose, and energy metabolism. Endogenous FGF21 is generated by …

[HTML][HTML] Primary sclerosing cholangitis, part 1: epidemiology, etiopathogenesis, clinical features, and treatment

JH Tabibian, AH Ali, KD Lindor - Gastroenterology & hepatology, 2018 - ncbi.nlm.nih.gov
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic cholangiopathy that can
progress to cirrhosis, end-stage liver disease, hepatobiliary cancer, and/or colorectal cancer …

Drug therapies for chronic cholestatic liver diseases

M Wagner, P Fickert - Annual review of pharmacology and …, 2020 - annualreviews.org
Though ursodeoxycholic acid (UDCA) remains the baseline treatment for most cholestatic
liver diseases, UDCA treatment leaves approximately one-third of patients with primary …

Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification

S Dai, R Wu, K Fu, Y Li, C Yao, Y Liu, F Zhang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Cholestatic liver injury (CLI) is a pathologic process with
the impairment of liver and bile secretion and excretion, resulting in an excessive …

[HTML][HTML] Primary sclerosing cholangitis: A review and update

JH Tabibian, CL Bowlus - Liver research, 2017 - Elsevier
Primary sclerosing cholangitis (PSC) is a rare, chronic, cholestatic liver disease of uncertain
etiology characterized biochemically by cholestasis and histologically and …

FGF21 acts as a negative regulator of bile acid synthesis

MM Chen, C Hale, S Stanislaus, J Xu… - Journal of …, 2018 - joe.bioscientifica.com
Fibroblast growth factor 21 (FGF21) is a potent regulator of glucose and lipid homeostasis in
vivo; its most closely related subfamily member, FGF19, is known to be a critical negative …

Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War …

RK Seth, D Kimono, F Alhasson, S Sarkar… - Toxicology and applied …, 2018 - Elsevier
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical
and pharmaceutical exposures during the war. Since an increased number of veterans …