[HTML][HTML] Current and future treatment strategies for rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, and can be
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
subcategorized histologically and/or based on PAX-FOXO1 fusion gene status. Over the last …
Insights into pediatric rhabdomyosarcoma research: Challenges and goals
ME Yohe, CM Heske, E Stewart… - Pediatric blood & …, 2019 - Wiley Online Library
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
(RMS) have not improved significantly since the 1980s. Recent studies have identified a …
DrugCombDB: a comprehensive database of drug combinations toward the discovery of combinatorial therapy
Drug combinations have demonstrated high efficacy and low adverse side effects compared
to single drug administration in cancer therapies and thus have drawn intensive attention …
to single drug administration in cancer therapies and thus have drawn intensive attention …
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …
Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma
Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers
(SEs) to activate transcription of cell-identity specifying gene networks, and are critical in …
(SEs) to activate transcription of cell-identity specifying gene networks, and are critical in …
[HTML][HTML] Chemical genomics reveals histone deacetylases are required for core regulatory transcription
BE Gryder, L Wu, GM Woldemichael, S Pomella… - Nature …, 2019 - nature.com
Identity determining transcription factors (TFs), or core regulatory (CR) TFs, are governed by
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …
cell-type specific super enhancers (SEs). Drugs to selectively inhibit CR circuitry are of high …
[PDF][PDF] ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion
T Eigler, G Zarfati, E Amzallag, S Sinha, N Segev… - Developmental cell, 2021 - cell.com
Myoblast fusion is essential for muscle development and regeneration. Yet, it remains poorly
understood how mononucleated myoblasts fuse with preexisting fibers. We demonstrate that …
understood how mononucleated myoblasts fuse with preexisting fibers. We demonstrate that …
MatchMaker: a deep learning framework for drug synergy prediction
Drug combination therapies have been a viable strategy for the treatment of complex
diseases such as cancer due to increased efficacy and reduced side effects. However …
diseases such as cancer due to increased efficacy and reduced side effects. However …
Single-cell profiling of alveolar rhabdomyosarcoma reveals RAS pathway inhibitors as cell-fate hijackers with therapeutic relevance
SG Danielli, E Porpiglia, AJ De Micheli, N Navarro… - Science …, 2023 - science.org
Rhabdomyosarcoma (RMS) is a group of pediatric cancers with features of developing
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
skeletal muscle. The cellular hierarchy and mechanisms leading to developmental arrest …
[HTML][HTML] Oncogenic super-enhancer formation in tumorigenesis and its molecular mechanisms
Q Jia, S Chen, Y Tan, Y Li, F Tang - Experimental & Molecular Medicine, 2020 - nature.com
Super-enhancers (SEs) consist of a cluster of many enhancers bound to a great number of
transcription factors. They are critical cis-regulatory elements that determine the identity of …
transcription factors. They are critical cis-regulatory elements that determine the identity of …