Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently in
malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1 …

As genomic sequencing has become more widely available, the high prevalence of Ras
pathway mutations in pediatric diseases has begun to emerge. Germline Ras-activating …

Recent characterizations of pioneer transcription factors provide insights into their structures
and patterns of chromatin recognition associated with their roles in cell fate commitment and …

Over the past few years, the field of pediatric cancer has experienced a shift in momentum,
and this has led to new and exciting findings that have relevance beyond pediatric …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
adolescents and accounts for approximately 2% of soft tissue sarcomas in adults. It is …

Single-cell RNA sequencing (scRNA-seq) greatly advanced the understanding of
intratumoral heterogeneity by identifying distinct cancer cell subpopulations. However …

Background Programmed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted
immunotherapy affords clinical benefit in~ 20% of unselected patients with lung cancer. The …

Oncogenic FOXO1 gene fusions drive a subset of rhabdomyosarcoma (RMS) with poor
survival; to date, these cancer drivers are therapeutically intractable. To identify new …

Methods developed to capture protein-anchored chromatin interactions (chromatin
interaction analysis by paired-end tag sequencing and HiChIP) have yielded tremendous …

In recent years, Hi-C technology has revolutionized cancer research by elucidating the
mystery of three-dimensional chromatin organization and its role in gene regulation. This …