Rhabdomyosarcoma is the most common soft tissue sarcoma diagnosed in children and
adolescents. Patients that are diagnosed with advanced or relapsed disease have …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype
characterised by extensive intratumoral heterogeneity, high rates of metastasis and …

RASopathies are rare developmental genetic syndromes caused by germline pathogenic
variants in genes that encode components of the RAS/mitogen-activated protein kinase …

Simple Summary Rhabdomyosarcoma is the most common soft tissue cancer in children
and adolescents. Its resemblance to skeletal muscle tissue distinguishes …

Localized prostate cancer develops very slowly in most men, with the androgen receptor
(AR) and MYC transcription factors amongst the most well-characterized drivers of prostate …

Simple Summary NanoString digital profiling methods are novel techniques to identify
biologic markers from human formalin-fixed, paraffin-embedded cancer tissue. We have …

Purpose: Deregulated metabolism in cancer cells represents a vulnerability that may be
therapeutically exploited to benefit patients. One such target is nicotinamide …

Rhabdomyosarcoma is a soft tissue cancer that arises in skeletal muscle due to mutations in
myogenic progenitors that lead to ineffective differentiation and malignant transformation …

The skeletal muscle is a highly plastic tissue that shows a remarkable adaptive capacity in
response to acute and resistance exercise, and modifies its composition to adapt to use and …

Cancer arises from genetic alterations that invariably contribute to dysregulated
transcriptional programs. These dysregulated programs establish and maintain specific …