Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Oxidative stress generated by an imbalance between reactive oxygen species (ROS) and
antioxidants contributes to the pathogenesis of arthritis, cancer, cardiovascular, liver and …

Mitochondria are important regulators of cellular function and survival that may have a key
role in aging-related diseases. Mitochondrial DNA (mtDNA) mutations and oxidative …

This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …

The reaction patterns of chondrocytes in osteoarthritis can be summarized in five
categories:(1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and …

Although the predominant mechanism of intra-articular hyaluronan (hyaluronic acid)(HA)
and hylans for the treatment of pain associated with knee osteoarthritis (OA) is unknown, in …

Matrix vesicles (MVs) are extracellular, 100 nM in diameter, membrane-invested particles
selectively located at sites of initial calcification in cartilage, bone, and predentin. The first …

Osteoarthritis (OA) has a considerable hereditary component and is considered to be a
polygenic disease. Data derived from genetic analyses and genome-wide screening of …