Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Despite the impressive clinical activity of the second-generation antiandrogens
enzalutamide and ARN-509 in patients with prostate cancer, acquired resistance invariably …

Objective Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …

Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders,
including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL …

Promising results have been shown with the combination of ponatinib and chemotherapy in
adults with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) …

Tyrosine kinase inhibitors have improved survival for patients with Philadelphia
chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for …

Understanding the direction of information flow is essential for characterizing how genetic
networks affect phenotypes. However, methods to find genetic interactions largely fail to …

Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …