[HTML][HTML] Small molecules in targeted cancer therapy: advances, challenges, and future perspectives
L Zhong, Y Li, L Xiong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …
Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: A novel therapeutic strategy
Abstract The phosphatidylinositol 3-kinase (PI3K)-Akt and the mammalian target of
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
rapamycin (mTOR) represent two vital intracellular signaling pathways, which are …
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade
ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …
A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509
JD Joseph, N Lu, J Qian, J Sensintaffar, G Shao… - Cancer discovery, 2013 - AACR
Despite the impressive clinical activity of the second-generation antiandrogens
enzalutamide and ARN-509 in patients with prostate cancer, acquired resistance invariably …
enzalutamide and ARN-509 in patients with prostate cancer, acquired resistance invariably …
Targeting PI3K/AKT/mTOR network for treatment of leukemia
J Bertacchini, N Heidari, L Mediani, S Capitani… - Cellular and molecular …, 2015 - Springer
Objective Increased activity of PI3K/AKT/mTOR pathway has been observed in a huge
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
number of malignancies. This pathway can function as a prosurvival factor in leukemia stem …
Molecular pathways: Bcr-abl
D Cilloni, G Saglio - Clinical Cancer Research, 2012 - AACR
Aberrant tyrosine kinase activity plays a critical role in many hematologic disorders,
including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL …
including chronic myeloid leukemia characterized by the constitutive activity of BCR-ABL …
Ponatinib, chemotherapy, and transplant in adults with Philadelphia chromosome–positive acute lymphoblastic leukemia
JM Ribera, O García-Calduch, J Ribera… - Blood …, 2022 - ashpublications.org
Promising results have been shown with the combination of ponatinib and chemotherapy in
adults with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) …
adults with Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) …
INCB84344-201: Ponatinib and steroids in frontline therapy for unfit patients with Ph+ acute lymphoblastic leukemia
G Martinelli, C Papayannidis, A Piciocchi… - Blood …, 2022 - ashpublications.org
Tyrosine kinase inhibitors have improved survival for patients with Philadelphia
chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for …
chromosome–positive (Ph+) acute lymphoblastic leukemia (ALL). However, prognosis for …
Dual gene activation and knockout screen reveals directional dependencies in genetic networks
M Boettcher, R Tian, JA Blau, E Markegard… - Nature …, 2018 - nature.com
Understanding the direction of information flow is essential for characterizing how genetic
networks affect phenotypes. However, methods to find genetic interactions largely fail to …
networks affect phenotypes. However, methods to find genetic interactions largely fail to …
A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA
Aberrant expression of long noncoding RNAs (lncRNAs) is associated with various human
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …
cancers. However, the role of lncRNAs in Bcr-Abl-mediated chronic myeloid leukemia (CML) …