On the molecular nature of large-pore channels

J Syrjanen, K Michalski, T Kawate… - Journal of molecular …, 2021 - Elsevier
Membrane transport is a fundamental means to control basic cellular processes such as
apoptosis, inflammation, and neurodegeneration and is mediated by a number of …

Coronary microvascular dysfunction

S Godo, A Suda, J Takahashi, S Yasuda… - … , and vascular biology, 2021 - Am Heart Assoc
Over the past couple of decades, accumulating evidence has shown that structural and
functional abnormalities of coronary microvasculature are highly prevalent, associated with …

Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells

K Diem, M Fauler, G Fois, A Hellmann… - The FASEB …, 2020 - Wiley Online Library
Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung
function. Stretching of alveoli during lung inflation is the main trigger for surfactant secretion …

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

AC Filiberto, MD Spinosa, CT Elder, G Su… - Nature …, 2022 - nature.com
Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Novel Smooth Muscle Ca2+-Signaling Nanodomains in Blood Pressure Regulation

YL Chen, Z Daneva, M Kuppusamy, M Ottolini… - Circulation, 2022 - Am Heart Assoc
Background: Ca2+ signals in smooth muscle cells (SMCs) contribute to vascular resistance
and control blood pressure. Increased vascular resistance in hypertension has been …

Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

Z Daneva, M Ottolini, YL Chen, E Klimentova… - Elife, 2021 - elifesciences.org
Abstract Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in
pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the …

Pannexin 1 as a driver of inflammation and ischemia–reperfusion injury

M Koval, A Cwiek, T Carr, ME Good, AW Lohman… - Purinergic …, 2021 - Springer
Abstract Pannexin 1 (Panx1) is a ubiquitously expressed protein forming large conductance
channels that are central to many distinct inflammation and injury responses. There is …

Pannexin biology and emerging linkages to cancer

DW Laird, S Penuela - Trends in cancer, 2021 - cell.com
Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …

Ion channels and vascular diseases

J Cheng, J Wen, N Wang, C Wang, Q Xu… - … , and vascular biology, 2019 - Am Heart Assoc
Transient receptor potential (TRP) channels are not only the major contributors to Ca2+
signaling but also the targets of Ca2+ signaling. Ca2+ regulation of TRP channels involves 3 …

Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

LJ DeLalio, M Billaud, CA Ruddiman… - Journal of Biological …, 2019 - ASBMB
Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-
adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently …