Cognitive impact of COVID-19: looking beyond the short term

S Miners, PG Kehoe, S Love - Alzheimer's research & therapy, 2020 - Springer
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …

The potential role of gut microbiota in Alzheimer's disease: from diagnosis to treatment

A Varesi, E Pierella, M Romeo, GB Piccini, C Alfano… - Nutrients, 2022 - mdpi.com
Gut microbiota is emerging as a key regulator of many disease conditions and its
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Lipids and Alzheimer's disease

YC Kao, PC Ho, YK Tu, IM Jou, KJ Tsai - International journal of molecular …, 2020 - mdpi.com
Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge …

LC Lee, CY Liong, AA Jemain - Analyst, 2018 - pubs.rsc.org
Partial least squares-discriminant analysis (PLS-DA) is a versatile algorithm that can be
used for predictive and descriptive modelling as well as for discriminative variable selection …

[HTML][HTML] The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Involvement of lipids in Alzheimer's disease pathology and potential therapies

H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

VR Varma, AM Oommen, S Varma, R Casanova… - PLoS …, 2018 - journals.plos.org
Background The metabolic basis of Alzheimer disease (AD) is poorly understood, and the
relationships between systemic abnormalities in metabolism and AD pathogenesis are …

Relationships of dietary patterns, foods, and micro-and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review

V Solfrizzi, C Custodero, M Lozupone… - Journal of …, 2017 - content.iospress.com
In the last decade, the association between diet and cognitive function or dementia has
been largely investigated. In the present article, we systematically reviewed observational …