Rationale: There is an association between body mass index (BMI) and mortality in chronic
obstructive pulmonary disease (COPD), with underweight individuals having higher mortality …

Background In asthma, inflammation affects both the proximal and distal airways and can
cause significant hyperinflation, which is thought to be a major cause of dyspnea. Methods …

Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is
associated with disease severity in patients with chronic obstructive pulmonary disease …

Severity of resting functional impairment only partially predicts the increased risk of death in
chronic obstructive pulmonary disease (COPD). Increased ventilation during exercise is …

The classification of chronic pulmonary obstructive disease (COPD) into clinical and
pathophysiological subsets is not new, but increasing data is available on the relation of …

Purpose Lung hyperinflation is a feature of chronic obstructive pulmonary disease (COPD)
and can determine pivotal consequence on symptoms, exercise tolerance and quality of life …

Background Decreased airway lumen size and increased lung volume are major structural
changes in chronic obstructive pulmonary disease (COPD). However, even though the outer …

Thin-section computed tomography (CT) is widely employed not only for assessing
morphology but also for evaluating respiratory function. Three-dimensional images obtained …

Background Severe hyperinflation causes detrimental effects such as dyspnea and reduced
exercise capacity and is an independent predictor of mortality in COPD patients. Static lung …

Endothelial injury is implicated in the pathogenesis of COPD and emphysema; however the
role of endothelial progenitor cells (EPCs), a marker of endothelial cell repair, and …