Therapeutic importance of kaempferol in the treatment of cancer through the modulation of cell signalling pathways

MY Qattan, MI Khan, SH Alharbi, AK Verma… - Molecules, 2022 - mdpi.com
Plant-derived flavonoids are considered natural nontoxic chemo-preventers and have been
widely studied for cancer treatment in recent decades. Mostly all flavonoid compounds show …

Reprogramming of lipid metabolism in lung cancer: An overview with focus on EGFR-Mutated non-small cell lung cancer

K Eltayeb, S La Monica, M Tiseo, R Alfieri, C Fumarola - Cells, 2022 - mdpi.com
Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …

GSH-responsive nanoprodrug to inhibit glycolysis and alleviate immunosuppression for cancer therapy

X Liu, Y Li, K Wang, Y Chen, M Shi, X Zhang… - Nano Letters, 2021 - ACS Publications
Blocking energy metabolism of cancer cells and simultaneously stimulating the immune
system to perform immune attack are significant for cancer treatment. However, how to …

Development and validation of a robust ferroptosis-related prognostic signature in lung adenocarcinoma

A Zhang, J Yang, C Ma, F Li, H Luo - Frontiers in Cell and …, 2021 - frontiersin.org
Background Lung adenocarcinoma (LUAD) is the most common subtype of non-small cell
lung cancer. Ferroptosis is a newly recognized process of cell death, which is different from …

Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review

Y Tian, C Duan, J Feng, J Liao, Y Yang… - The International Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. Several lung …

Prognostic implication of a metabolism-associated gene signature in lung adenocarcinoma

L He, J Chen, F Xu, J Li - Molecular Therapy-Oncolytics, 2020 - cell.com
Lung cancer is the most common cancer worldwide, leading to high mortality each year.
Metabolic pathways play a vital role in the initiation and progression of lung cancer. We …

[HTML][HTML] Friend or foe? An unrecognized role of uric acid in cancer development and the potential anticancer effects of uric acid-lowering drugs

S Mi, L Gong, Z Sui - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists.
Mets has an intimate relationship with the incidence and development of various cancers. As …

Comprehensive analysis of a novel signature incorporating lipid metabolism and immune-related genes for assessing prognosis and immune landscape in lung …

Y Wang, J Xu, Y Fang, J Gu, F Zhao, Y Tang… - Frontiers in …, 2022 - frontiersin.org
Background As the crosstalk between metabolism and antitumor immunity continues to be
unraveled, we aim to develop a prognostic gene signature that integrates lipid metabolism …

Ubiquitination links DNA damage and repair signaling to cancer metabolism

SY Koo, EJ Park, HJ Noh, SM Jo, BK Ko… - International Journal of …, 2023 - mdpi.com
Changes in the DNA damage response (DDR) and cellular metabolism are two important
factors that allow cancer cells to proliferate. DDR is a set of events in which DNA damage is …

The role of MicroRNAs in lung cancer metabolism

MIHN Azizi, I Othman, R Naidu - Cancers, 2021 - mdpi.com
Simple Summary Tumor cells exhibit dysregulation in metabolic activities compared with
normal cells. Lung cancer is one of the most commonly diagnosed cancers globally. Studies …