Alcohol and other drugs of abuse, including psychostimulants and opioids, can induce
epigenetic changes: a contributing factor for drug addiction, tolerance, and associated …

Rationale Exposure to drugs during adolescence can induce alterations in the central
nervous system. The novelty-seeking personality trait influences differences observed …

Rationale Prepulse inhibition (PPI) of the startle reflex is a model of pre-attentional inhibitory
function. The dopamine baseline in the nucleus accumbens plays a key role in PPI …

A novel approach to the treatment of adverse effects of drugs of abuse is one which makes
use of natural products. The present study investigated the effect of Rhodiola rosea L …

The prepulse inhibition (PPI) of the startle response can identify the rodents that are more
sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to …

Rationale Rats develop preferences for places associated with the immediate rewarding
effects of cocaine and aversions for places paired with the drug's delayed negative effects …

Rationale Topiramate is an anticonvulsant drug which has been evaluated as a therapeutic
option for the treatment of cocaine addiction during the last decade. Objectives The purpose …

Neurotensin (NT) is a neuropeptide that acts as a neurotransmitter and neuromodulator in
the central nervous system. Several studies suggest a therapeutic role for NT analogs in …

Although the consumption of cocaine is frequent in young users of MDMA (3, 4-
methylenedioxymethamphetamine), the influence of exposure to cocaine on the rewarding …

A main challenge for addiction research is to identify the factors that predispose individuals
to drug addiction. Novelty-or sensation-seeking is a personality trait which partly explains …