One of the malignant tumors in women that has involved both developed and developing
countries is breast cancer. Similar to other types of tumors, breast cancer cells demonstrate …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Background Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs)
play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in …

Approximately 30% of breast cancer survivors deemed free of disease will experience
locoregional or metastatic recurrence even up to 30 years after initial diagnosis, yet how …

Inter-patient and intra-tumoral heterogeneity complicate the identification of predictive
biomarkers and effective treatments for basal triple negative breast cancer (b-TNBC) …

Tumor metastasis is the main reason for cancer-related death, but there is still a lack of
effective therapeutic to inhibit tumor metastasis. Therefore, the discovery and study of new …

Background Polyploid giant cancer cells (PGCCs), a specific type of cancer stem cells
(CSCs), can be induced by hypoxic microenvironments, chemical reagents, radiotherapy …

Epithelial-to-mesenchymal transition (EMT), a biological phenomenon of cellular plasticity
initially reported in embryonic development, has been increasingly recognized for its …

Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype among breast
cancers (BCs), characterized by anoikis resistance, high invasiveness, and metastatic …