Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Bitter taste receptors (TAS2Rs or T2Rs) belong to the superfamily of seven-transmembrane
G protein–coupled receptors, which are the targets of> 50% of drugs currently on the market …

Taste sensing is a sophisticated chemosensory process, and bitter taste perception is
mediated by type 2 taste receptors (TAS2Rs), or class TG protein–coupled receptors …

Humans perceive thousands of compounds as bitter. In sharp contrast, only∼ 25 taste 2
receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how …

The chemical senses (smell and taste) have evolved complex repertoires of chemosensory
receptors—G-protein coupled receptors with a seven-transmembrane domain structure. In …

One key to animal survival is the detection and avoidance of potentially harmful compounds
by their bitter taste. Variable numbers of taste 2 receptor genes expressed in the gustatory …

Umami is one of the 5 basic taste qualities. The umami taste of L-glutamate can be
drastically enhanced by 5′ ribonucleotides and the synergy is a hallmark of this taste …

Bitterness is a major sensory attribute of several common foods and beverages rich in
polyphenol compounds. These compounds are reported as very important for health as …

Weight-conscious subjects and diabetics use the sulfonyl amide sweeteners saccharin and
acesulfame K to reduce their calorie and sugar intake. However, the intrinsic bitter aftertaste …

Steviol glycosides, the sweet principle of Stevia Rebaudiana (Bertoni) Bertoni, have recently
been approved as a food additive in the EU. The herbal non-nutritive high-potency …