Drp1-dependent mitochondrial fission in cardiovascular disease

J Jin, X Wei, X Zhi, X Wang, D Meng - Acta Pharmacologica Sinica, 2021 - nature.com
Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …

Anti-cancer peptides: classification, mechanism of action, reconstruction and modification

M Xie, D Liu, Y Yang - Open biology, 2020 - royalsocietypublishing.org
Anti-cancer peptides (ACPs) are a series of short peptides composed of 10–60 amino acids
that can inhibit tumour cell proliferation or migration, or suppress the formation of tumour …

Protein acylation: mechanisms, biological functions and therapeutic targets

S Shang, J Liu, F Hua - Signal Transduction and Targeted Therapy, 2022 - nature.com
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

L Hu, M Chen, X Chen, C Zhao, Z Fang, H Wang… - Cell death & …, 2020 - nature.com
Many chemotherapy treatments induce apoptosis or pyroptosis through BAK/BAX-
dependent mitochondrial pathway. BAK/BAX activation causes the mitochondrial outer …

Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging

W Chyan, RT Raines - ACS chemical biology, 2018 - ACS Publications
Fluorogenic probes, small-molecule sensors that unmask brilliant fluorescence upon
exposure to specific stimuli, are powerful tools for chemical biology. Those probes that …

Protein palmitoylation in cancer: molecular functions and therapeutic potential

B Zhou, Q Hao, Y Liang, E Kong - Molecular oncology, 2023 - Wiley Online Library
Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …

Protein palmitoylation and its pathophysiological relevance

J Jin, X Zhi, X Wang, D Meng - Journal of cellular physiology, 2021 - Wiley Online Library
Protein palmitoylation, in which C16 fatty acid chains are attached to cysteine residues via a
reversible thioester linkage, is one of the most common lipid modifications and plays …

Dynamic protein acylation: new substrates, mechanisms, and drug targets

T Lanyon-Hogg, M Faronato, RA Serwa… - Trends in biochemical …, 2017 - cell.com
Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …

Substrate recruitment by zDHHC protein acyltransferases

MIP Malgapo, ME Linder - Open biology, 2021 - royalsocietypublishing.org
Protein palmitoylation is the post-translational attachment of fatty acids, most commonly
palmitate (C16: 0), onto a cysteine residue of a protein. This reaction is catalysed by a family …

Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase

F Plain, J Howie, J Kennedy, E Brown… - Communications …, 2020 - nature.com
Although palmitoylation regulates numerous cellular processes, as yet efforts to manipulate
this post-translational modification for therapeutic gain have proved unsuccessful. The Na …