Inducible nitric oxide synthase: Regulation, structure, and inhibition
MA Cinelli, HT Do, GP Miley… - Medicinal research …, 2020 - Wiley Online Library
A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …
Nitric oxide synthases: structure, function and inhibition
WK Alderton, CE Cooper, RG Knowles - Biochemical journal, 2001 - portlandpress.com
This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …
inhibition made in the last seven years, during which time substantial advances have been …
Endothelial nitric oxide synthase in vascular disease: from marvel to menace
U Forstermann, T Münzel - Circulation, 2006 - Am Heart Assoc
Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
JA Wells, CL McClendon - Nature, 2007 - nature.com
Targeting the interfaces between proteins has huge therapeutic potential, but discovering
small-molecule drugs that disrupt protein–protein interactions is an enormous challenge …
small-molecule drugs that disrupt protein–protein interactions is an enormous challenge …
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Developing small molecules that modulate protein …
opportunities for therapeutic intervention. Developing small molecules that modulate protein …
[HTML][HTML] Oncogenic protein interfaces: small molecules, big challenges
Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …
possible because the corresponding interfaces were considered mostly flat and featureless …
Small-molecule inhibition of TNF-α
MM He, AS Smith, JD Oslob, WM Flanagan… - Science, 2005 - science.org
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that
promotes subunit disassembly of this trimeric cytokine family member. The compound …
promotes subunit disassembly of this trimeric cytokine family member. The compound …
Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity
MC Smith, JE Gestwicki - Expert reviews in molecular medicine, 2012 - cambridge.org
Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …
thus, these contacts have enormous potential as drug targets. However, the field has …
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
M Perreault, A Marette - Nature medicine, 2001 - nature.com
Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in skeletal
muscle and fat. It has been proposed that chronic iNOS induction may cause muscle insulin …
muscle and fat. It has been proposed that chronic iNOS induction may cause muscle insulin …
Structure of a V3-containing HIV-1 gp120 core
C Huang, M Tang, MY Zhang, S Majeed, E Montabana… - Science, 2005 - science.org
The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant
and contains features essential for coreceptor binding. We determined the structure of V3 in …
and contains features essential for coreceptor binding. We determined the structure of V3 in …