A considerable number of human diseases have an inflammatory component, and a key
mediator of immune activation and inflammation is inducible nitric oxide synthase (iNOS) …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …

Targeting the interfaces between proteins has huge therapeutic potential, but discovering
small-molecule drugs that disrupt protein–protein interactions is an enormous challenge …

Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Developing small molecules that modulate protein …

Historically, targeting protein–protein interactions with small molecules was not thought
possible because the corresponding interfaces were considered mostly flat and featureless …

We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that
promotes subunit disassembly of this trimeric cytokine family member. The compound …

Protein–protein interactions (PPIs) control the assembly of multi-protein complexes and,
thus, these contacts have enormous potential as drug targets. However, the field has …

Inducible nitric oxide synthase (iNOS) is induced by inflammatory cytokines in skeletal
muscle and fat. It has been proposed that chronic iNOS induction may cause muscle insulin …

The third variable region (V3) of the HIV-1 gp120 envelope glycoprotein is immunodominant
and contains features essential for coreceptor binding. We determined the structure of V3 in …