Exocrine pancreatic insufficiency (EPI), an important cause of maldigestion and
malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine …

Although it is well established that type 2 diabetes (T2D) is generally due to the progressive
loss of β-cell insulin secretion against a background of insulin resistance, the actual …

Ethnopharmacological relevance Dendrobium officinale polysaccharide (DOP) is the main
active ingredient of Dendrobium officinale Kimura & Migo, which is a precious traditional …

Understanding the regulation of islet cell mass has important implications for the discovery
of regenerative therapies for diabetes. The liver plays a central role in metabolism and the …

Glucagon is a critical regulator of glucose homeostasis; however, mechanisms regulating
glucagon action and α-cell function and number are incompletely understood. To elucidate …

Objective: Spinal muscular atrophy (SMA) is the number 1 genetic killer of young children. It
is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Although …

Eating a “Westernized” diet high in fat and sugar leads to weight gain and numerous health
problems, including the development of type 2 diabetes mellitus (T2DM). Rodent studies …

Hyperglucagonemia is one of the 'ominous' eight factors underlying the pathogenesis of type
2 diabetes (T2D). Glucagon is a peptide hormone involved in maintaining glucose …

Pregnancy and obesity are frequently associated with diminished insulin sensitivity, which is
normally compensated for by an expansion of the functional β cell mass that prevents …

OBJECTIVE The role of uncoupling protein 2 (UCP2) in pancreatic β-cells is highly debated,
partly because of the broad tissue distribution of UCP2 and thus limitations of whole-body …