In the year 2000, Hanahan and Weinberg (1) defined the six Hallmarks of Cancer as: self-
sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms …

Disturbance of protein kinase activity may result in dramatic consequences that often lead to
cancer development and progression. In tumors of blood origin, both tyrosine kinases and …

High levels of circulating miR-16 in the serum of multiple myeloma (MM) patients are
independently associated with longer survival. Although the tumor suppressor function of …

Recent evidence indicates that protein kinase CK1α may support the growth of multiple
myeloma (MM) plasma cells. Here, by analyzing a large cohort of MM cases, we found that …

Multiple myeloma (MM) is a malignant tumor of transformed plasma cells. MM pathogenesis
is a multistep process. This cancer can occur de novo (rarely) or it can develop from …

Multiple myeloma (MM) is a tumor of plasma cells (PCs). Due to the intense immunoglobulin
secretion, PCs are prone to endoplasmic reticulum stress and activate several stress …

Introduction: Significant advances have been made during the last two decades in terms of
new therapeutic options but also of innovative approaches to diagnosis and management of …

Simple Summary Multiple myeloma (MM) is an incurable disease for which novel
therapeutic approaches targeting the malignant cells and the associated bone disease are …

Genetic mutations of oncogenes often underlie deranged cell growth and altered
differentiation pathways leading to malignant transformation of B-lymphocytes. However …

Introduction In classical Hodgkin lymphoma (cHL), the survival of neoplastic cells is
mediated by the activation of NF-κB, JAK/STAT and PI3K/Akt signaling pathways. CK2 is a …