Wide disparities in obstetric outcomes exist between women of different race/ethnicities. The
prevalence of preterm birth, fetal growth restriction, fetal demise, maternal mortality, and …

The influence of folate nutritional status on various pregnancy outcomes has long been
recognized. Studies conducted in the 1950s and 1960s led to the recognition of prenatal …

Background Hemangiomas of infancy vary widely in appearance, size, and depth of
cutaneous involvement. There is currently no standard classification system for these …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

Objective. In an effort to reduce the occurrence of neural tube defects (NTDs), folic acid
fortification of US enriched grain products was authorized by the Food and Drug …

Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism by
channeling one-carbon units between nucleotide synthesis and methylation reactions …

▪ Abstract DNA methylation at cytosines in CpG dinucleotides can lead to changes in gene
expression and function without altering the primary sequence of the DNA. Methylation can …

Neural tube defects (NTDs), including anencephaly and spina bifida, arise from the failure of
neurulation during early embryonic development. Neural tube defects are common birth …

It is generally understood that both genetic and environmental factors contribute to the highly
complex etiology of structural birth defects, including neural tube defects, oral clefts and …

Neural tube defects (NTDs) refer to a cluster of neurodevelopmental conditions associated
with failure of neural tube closure during embryonic development. Worldwide prevalence of …