Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations

Y Xu, Z Jiang, X Chen - European Journal of Pharmacology, 2022 - Elsevier
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …

Neutrophil biology in injuries and diseases of the central and peripheral nervous systems

BM Balog, A Sonti, RE Zigmond - Progress in Neurobiology, 2023 - Elsevier
The role of inflammation in nervous system injury and disease is attracting increased
attention. Much of that research has focused on microglia in the central nervous system …

[HTML][HTML] Differential effects of regulatory T cells in the meninges and spinal cord of male and female mice with neuropathic pain

NT Fiore, BA Keating, Y Chen, SI Williams… - Cells, 2023 - mdpi.com
Immune cells play a critical role in promoting neuroinflammation and the development of
neuropathic pain. However, some subsets of immune cells are essential for pain resolution …

“Nociplastic pain”: a challenge to nosology and to nociception

M Cohen, J Quintner, A Weisman - The journal of pain, 2023 - Elsevier
The construct of “nociplastic pain” has met with divergent receptions. On the one hand it has
been enthusiastically embraced, to the extent of conflation with central sensitization of …

Trimethoxyflavanone relieves paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice

C Mei, C Pan, L Xu, M Miao, Q Lu, Y Yu, P Lin, W Wu… - …, 2023 - Elsevier
Paclitaxel (PTX) is an anticancer drug used to treat solid tumors, but one of its common
adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is …

[HTML][HTML] New insight into the agonism of protease-activated receptors as an immunotherapeutic strategy

Y Jiang, L Lu - Journal of Biological Chemistry, 2023 - Elsevier
The activation and mobilization of immune cells play a crucial role in immunotherapy.
Existing therapeutic interventions, such as cytokines administration, aim to enhance immune …

[HTML][HTML] Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity

JM Inclan-Rico, HL Rossi, RH De'Broski - Mucosal immunology, 2022 - Elsevier
Helminths are remarkably successful parasites that can invade various mammalian hosts
and establish chronic infections that can go unnoticed for years despite causing severe …

[HTML][HTML] Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice

NT Fiore, JP Hayes, SI Williams… - Brain, Behavior, and …, 2024 - Elsevier
Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …

Lumbosacral zone features in individuals with nonspecific chronic low back pain are unique compared to controls and correlate with pain and dysfunction

S Abu-Leil, A Weisman, N Peled, H Kasem, G Dar… - European …, 2023 - Springer
Objectives To compare the lumbosacral nerve distances (LNDs) and sacroiliac joint (SIJ)
morphology in individuals with nonspecific chronic low back pain (NSCLBP) and control and …

[HTML][HTML] Glucose competition between endothelial cells in the blood-spinal cord barrier and infiltrating regulatory T cells is linked to sleep restriction-induced …

Y Huang, R Xu, Q Liu, X Zhang, Y Mao, Y Yang, X Gu… - BMC medicine, 2024 - Springer
Background Sleep loss is a common public health problem that causes hyperalgesia,
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …