Mechanisms underlying paclitaxel-induced neuropathic pain: Channels, inflammation and immune regulations
Paclitaxel is a chemotherapeutic agent widely used for many types of malignancies.
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
However, when paclitaxel is used to treat tumors, patients commonly experience severe …
Neutrophil biology in injuries and diseases of the central and peripheral nervous systems
BM Balog, A Sonti, RE Zigmond - Progress in Neurobiology, 2023 - Elsevier
The role of inflammation in nervous system injury and disease is attracting increased
attention. Much of that research has focused on microglia in the central nervous system …
attention. Much of that research has focused on microglia in the central nervous system …
[HTML][HTML] Differential effects of regulatory T cells in the meninges and spinal cord of male and female mice with neuropathic pain
NT Fiore, BA Keating, Y Chen, SI Williams… - Cells, 2023 - mdpi.com
Immune cells play a critical role in promoting neuroinflammation and the development of
neuropathic pain. However, some subsets of immune cells are essential for pain resolution …
neuropathic pain. However, some subsets of immune cells are essential for pain resolution …
“Nociplastic pain”: a challenge to nosology and to nociception
M Cohen, J Quintner, A Weisman - The journal of pain, 2023 - Elsevier
The construct of “nociplastic pain” has met with divergent receptions. On the one hand it has
been enthusiastically embraced, to the extent of conflation with central sensitization of …
been enthusiastically embraced, to the extent of conflation with central sensitization of …
Trimethoxyflavanone relieves paclitaxel-induced neuropathic pain via inhibiting expression and activation of P2X7 and production of CGRP in mice
C Mei, C Pan, L Xu, M Miao, Q Lu, Y Yu, P Lin, W Wu… - …, 2023 - Elsevier
Paclitaxel (PTX) is an anticancer drug used to treat solid tumors, but one of its common
adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is …
adverse effects is chemotherapy-induced peripheral neuropathy (CIPN). Currently, there is …
[HTML][HTML] New insight into the agonism of protease-activated receptors as an immunotherapeutic strategy
Y Jiang, L Lu - Journal of Biological Chemistry, 2023 - Elsevier
The activation and mobilization of immune cells play a crucial role in immunotherapy.
Existing therapeutic interventions, such as cytokines administration, aim to enhance immune …
Existing therapeutic interventions, such as cytokines administration, aim to enhance immune …
[HTML][HTML] Every cell is an immune cell; contributions of non-hematopoietic cells to anti-helminth immunity
JM Inclan-Rico, HL Rossi, RH De'Broski - Mucosal immunology, 2022 - Elsevier
Helminths are remarkably successful parasites that can invade various mammalian hosts
and establish chronic infections that can go unnoticed for years despite causing severe …
and establish chronic infections that can go unnoticed for years despite causing severe …
[HTML][HTML] Interleukin-35 alleviates neuropathic pain and induces an anti-inflammatory shift in spinal microglia in nerve-injured male mice
NT Fiore, JP Hayes, SI Williams… - Brain, Behavior, and …, 2024 - Elsevier
Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …
Lumbosacral zone features in individuals with nonspecific chronic low back pain are unique compared to controls and correlate with pain and dysfunction
Objectives To compare the lumbosacral nerve distances (LNDs) and sacroiliac joint (SIJ)
morphology in individuals with nonspecific chronic low back pain (NSCLBP) and control and …
morphology in individuals with nonspecific chronic low back pain (NSCLBP) and control and …
[HTML][HTML] Glucose competition between endothelial cells in the blood-spinal cord barrier and infiltrating regulatory T cells is linked to sleep restriction-induced …
Y Huang, R Xu, Q Liu, X Zhang, Y Mao, Y Yang, X Gu… - BMC medicine, 2024 - Springer
Background Sleep loss is a common public health problem that causes hyperalgesia,
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …
especially that after surgery, which reduces the quality of life seriously. Methods The 48-h …