INTRODUCTION During development, brain circuits go through phases of synapse
formation, stabilization, or elimination. γ-aminobutyric acid–mediated (GABAergic) synapse …

Synaptic plasticity in the adult brain is believed to represent the cellular mechanisms of
learning and memory. Mitochondria are involved in the regulation of the complex processes …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

P2X7 receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies
of individual subunits. They are widely distributed at immunocompetent cells of the central …

This review discusses the evidence supporting a role for ATP signaling (operated by P 2 X
and P 2 Y receptors) and adenosine signaling (mainly operated by A 1 and A 2A receptors) …

Abstract Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …

The adenosine receptors (ARs) in the nervous system act as a kind of “go-between” to
regulate the release of neurotransmitters (this includes all known neurotransmitters) and the …

Adenosine triphosphate (ATP) acts as a fast excitatory transmitter in several regions of the
central nervous system (CNS) including the medial habenula, dorsal horn, locus coeruleus …

Recent studies combining pharmacological, behavioral, electrophysiological and molecular
approaches indicate that depression results from maladaptive neuroplastic processes …

Fast synaptic transmission depends on the selective ionic permeability of transmitter-gated
ion channels. Here we show changes in the ion selectivity of neuronal P2X transmitter-gated …