A short ischemic period induced by the transient occlusion of major brain arteries induces
neuronal damage in selectively vulnerable regions of the hippocampus. Adenosine is …

The hippocampal GABAergic system is assumed not to be a target for purine modulation.
We have now confirmed that neither adenosine A1 and A3 receptor nor nucleotide P2 or P4 …

Recent studies highlighted the importance of astrocyte-secreted molecules, such as ATP, for
the slow modulation of synaptic transmission in central neurones. Biophysical mechanisms …

The excitatory action of brain-derived neurotrophic factor (BDNF) on synaptic transmission is
triggered by adenosine A2A receptor activation. Since high-frequency neuronal firing, such …

Various experimental approaches have been used to determine the concentration of
adenosine in extracellular brain fluid. The cortical cup technique or the microdialysis …

Adenosine is a signaling molecule and downstream product of ATP that acts as a
neuromodulator. Adenosine regulates physiological processes, such as neurotransmission …

Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940's,
but cloning and characterisation of receptors for purines and pyrimidines did not take place …

ATP is known to be coreleased with glutamate at certain central synapses. However, the
nature of its release is controversial. Here, we demonstrate that ATP release from cultured …

In the central nervous system (CNS) ATP and adenosine act as transmitters and
neuromodulators on their own receptors but it is still unknown which part of extracellular …

Adenosine A2A receptors (A2AR) control fear memory and the underlying processes of
synaptic plasticity in the amygdala. In other brain regions, A2AR activation is ensured by …