The phospholipase A2 (PLA2) superfamily contains more than 50 enzymes in mammals that
are subdivided into several distinct families on a structural and biochemical basis. In …

Lipid droplets are fat storage organelles present in most eukaryotic cells. They consist of a
neutral lipid core containing mostly triglycerides and sterol esters and covered by a …

Extracellular vesicles (EVs) including exosomes act as intercellular communicators by
transferring protein and microRNA cargoes, yet the role of EV lipids remains unclear. Here …

Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …

Abstract Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …

Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted
phospholipase A 2 (sPLA 2-IIA) prevents bacterial infection by degrading bacterial …

Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Abstract Objectives Polyunsaturated fatty acids (PUFAs) are structural components of
membrane phospholipids and precursors of oxygenated lipid mediators with diverse …

Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane
signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are …

Within the phospholipase A 2 (PLA 2) superfamily, secreted PLA 2 (sPLA 2) enzymes
comprise the largest family that contains 11 to 12 mammalian isoforms with a conserved His …