From Nucleosomes to Compartments: Physicochemical Interactions Underlying Chromatin Organization
Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …
genetic information. However, understanding chromatin folding is challenging due to its …
Topological spectra and entropy of chromatin loop networks
The 3D folding of a mammalian gene can be studied by a polymer model, where the
chromatin fiber is represented by a semiflexible polymer which interacts with multivalent …
chromatin fiber is represented by a semiflexible polymer which interacts with multivalent …
A mean-field theory for predicting single polymer collapse induced by neutral crowders
Q Chaboche, G Campos-Villalobos, G Giunta… - Soft Matter, 2024 - pubs.rsc.org
Macromolecular crowding can induce the collapse of a single long polymer into a globular
form due to depletion forces of entropic nature. This phenomenon has been shown to play a …
form due to depletion forces of entropic nature. This phenomenon has been shown to play a …
Regulation of chromatin architecture by transcription factor binding
S Portillo-Ledesma, S Chung, J Hoffman, T Schlick - Elife, 2024 - elifesciences.org
Transcription factors (TF) bind to chromatin and regulate the expression of genes. The pair
Myc: Max binds to E-box regulatory DNA elements throughout the genome to control the …
Myc: Max binds to E-box regulatory DNA elements throughout the genome to control the …
OpenNucleome for high-resolution nuclear structural and dynamical modeling
Z Lao, B Zhang - Biophysical Journal, 2024 - cell.com
The intricate structural organization of the human nucleus is fundamental to cellular function
and gene regulation. Recent advancements in experimental techniques, including high …
and gene regulation. Recent advancements in experimental techniques, including high …
Protein search processes mediated by chromatin topology
S Dutta, R Padinhateeri, MK Mitra - Biophysical Journal, 2024 - cell.com
The kinetics of protein motion on DNA is linked inextricably with the topology of the polymer
itself. Collapsed conformations of chromatin, characterized by long loops which bring distant …
itself. Collapsed conformations of chromatin, characterized by long loops which bring distant …