Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their
precursor in the world of natural compounds. Apart from their fundamental neuroleptic action …

The membrane transport protein P-glycoprotein (P-gp) is an interesting candidate for
individual differences in response to antipsychotics. To present an overview of the current …

Background KRISTINE is an open-label, phase III study of trastuzumab emtansine+
pertuzumab (T-DM1+ P) versus docetaxel+ carboplatin+ trastuzumab+ pertuzumab (TCH+ …

CYP2D6 plays a major role in the metabolism of tamoxifen, and polymorphism of P-
glycoprotein has been associated with resistance of many drug therapies. This study …

Small interfering ribonucleic acids (siRNAs) are originally recognized as an intermediate of
the RNA interference (RNAi) pathway. They can inhibit or silence various cellular pathways …

Abstract Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux
pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P …

Purpose Oxaliplatin or irinotecan is usually administered jointly with fluoropyrimidines in
colorectal cancer patients treated with chemotherapy. Both drugs have different toxicity …

Background P-glycoprotein, the product of the MDR1 gene, is a transmembrane active efflux
pump for a variety of environmental toxins and xenobiotics. Epidemiological studies have …

Background: MDR1, one of the most important drug-transporter genes, encodes P-
glycoprotein (P-gp)-a transporter involved in protecting against xenobiotics and multi-drug …

Purpose Genetic variants of ABCB1 gene contributed to cancer susceptibility and
interindividual differences in chemotherapy response. Therefore, we investigated the …